Seema Briyal Selected Research

Endothelin B Receptor

9/2020	Sovateltide (IRL-1620) affects neuronal progenitors and prevents cerebral tissue damage after ischemic stroke.
1/2020	Sovateltide (IRL-1620) activates neuronal differentiation and prevents mitochondrial dysfunction in adult mammalian brains following stroke.
1/2019	Anti-apoptotic activity of ETB receptor agonist, IRL-1620, protects neural cells in rats with cerebral ischemia.
6/2012	Endothelin B receptor agonist, IRL-1620, provides long-term neuroprotection in cerebral ischemia in rats.
10/2011	Endothelin B receptor agonist, IRL-1620, reduces neurological damage following permanent middle cerebral artery occlusion in rats.

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Seema Briyal Research Topics

Disease

8	Brain Ischemia (Cerebral Ischemia) 09/2020 - 04/2010
6	Stroke (Strokes) 01/2020 - 10/2004
5	Infarction (Infarctions) 09/2020 - 10/2010
5	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 06/2012 - 05/2005
4	Ischemic Stroke 09/2020 - 05/2005
4	Seizures (Absence Seizure) 12/2010 - 01/2002
3	Hypothermia 01/2022 - 10/2010
3	Ischemia 01/2021 - 05/2005
2	Brain Hypoxia-Ischemia (Hypoxia Ischemia, Brain) 01/2022 - 01/2020
2	Hypoxia (Hypoxemia) 01/2020 - 04/2006
2	Mitochondrial Diseases (Mitochondrial Disease) 01/2020 - 01/2020
2	Cognitive Dysfunction 05/2014 - 01/2011
2	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2011 - 10/2005
2	Alzheimer Disease (Alzheimer's Disease) 01/2011 - 10/2005
1	Hemorrhagic Shock 01/2021
1	Critical Illness (Critically Ill) 01/2020
1	Pain (Aches) 01/2020
1	Apnea 01/2020
1	Acute Kidney Injury (Acute Renal Failure) 11/2017
1	Body Weight (Weight, Body) 06/2017
1	Brain Edema (Cerebral Edema) 06/2012
1	Diabetes Mellitus 01/2012
1	Hypertension (High Blood Pressure) 12/2010
1	Neurologic Manifestations (Neurological Manifestations) 10/2010
1	Cerebral Infarction 04/2010
1	Brain Injuries (Brain Injury) 04/2010
1	Status Epilepticus (Complex Partial Status Epilepticus) 02/2006
1	Epilepsy (Aura) 01/2002

Drug/Important Bio-Agent (IBA)

9	sovateltideIBA 01/2022 - 10/2011
6	AntioxidantsIBA 01/2020 - 01/2002
5	Endothelin B ReceptorIBA 09/2020 - 10/2011
4	Endothelins (Endothelin)IBA 01/2020 - 01/2011
4	Malondialdehyde (Propanedial)IBA 01/2012 - 02/2006
3	Neuroprotective AgentsIBA 01/2022 - 04/2006
3	Glutathione (Reduced Glutathione)IBA 01/2012 - 10/2010
3	cyclo(Trp-Asp-Pro-Val-Leu)IBA 01/2012 - 10/2010
3	Endothelin Receptor AntagonistsIBA 10/2010 - 05/2005
3	Kainic Acid (Kainate)IBA 01/2009 - 01/2002
2	Morphine (MS Contin)FDA LinkGeneric 01/2020 - 06/2017
2	Free RadicalsIBA 01/2020 - 04/2010
2	Streptozocin (Streptozotocin)FDA Link 05/2014 - 10/2005
2	Endothelin Receptors (Endothelin Receptor)IBA 05/2014 - 06/2012
2	BQ 788IBA 05/2014 - 10/2011
2	Endothelin A ReceptorIBA 06/2012 - 10/2010
2	Superoxide DismutaseIBA 01/2012 - 10/2011
2	TAK 044IBA 04/2006 - 05/2005
2	ResveratrolIBA 10/2005 - 01/2002
1	centhaquineIBA 01/2021
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2020
1	CB2 Cannabinoid ReceptorIBA 01/2020
1	Macrophage Inflammatory Proteins (Macrophage Inflammatory Protein 1)IBA 01/2020
1	Caffeine (No Doz)FDA LinkGeneric 01/2020
1	1,1-dimethylbutyl-1-deoxy-Delta(9)-THCIBA 01/2020
1	Vancomycin FDA LinkGeneric 11/2017
1	Biomarkers (Surrogate Marker)IBA 11/2017
1	Oxycodone (Oxycontin)FDA LinkGeneric 06/2017
1	Amyloid beta-PeptidesIBA 05/2014
1	Exenatide (Byetta)FDA Link 01/2012
1	Glucagon-Like Peptide 1 (GLP 1)IBA 01/2012
1	Endothelin-1 (Endothelin 1)IBA 10/2011
1	Proteins (Proteins, Gene)FDA Link 10/2011
1	Endothelin A Receptor AntagonistsIBA 01/2011
1	Amyloid (Amyloid Fibrils)IBA 01/2011
1	Clonidine (ST 155)FDA LinkGeneric 12/2010
1	Hypnotics and Sedatives (Sedatives)IBA 12/2010
1	Acetaminophen (Paracetamol)FDA LinkGeneric 10/2010
1	Tissue Plasminogen Activator (Alteplase)FDA Link 04/2010
1	Neurotransmitter Agents (Neurotransmitter)IBA 04/2010
1	CurcuminIBA 01/2009
1	Glucose (Dextrose)FDA LinkGeneric 04/2006
1	Oxygen (Dioxygen)IBA 04/2006
1	vineatrolIBA 02/2006
1	Heat-Shock Proteins (Heat-Shock Protein)IBA 02/2006
1	MelatoninIBA 10/2005
1	Thioctic Acid (Lipoic Acid)IBA 10/2005
1	Cyclooxygenase 2 Inhibitors (COX-2 Inhibitors)IBA 10/2004
1	Calcium Channel Blockers (Blockers, Calcium Channel)IBA 10/2004
1	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 10/2004
1	Plant Preparations (Preparation, Plant)IBA 10/2004
1	Pharmaceutical PreparationsIBA 10/2004

Therapy/Procedure

5	Therapeutics 01/2020 - 01/2002
2	Induced Hypothermia 01/2022 - 10/2010
1	Thrombolytic Therapy 04/2010